| Oral mucositis |
Mucosal cytotoxicity |
Decreased local/systemic immunity: local infections, reactivation of HSV |
| Physical/chemical trauma |
| Oral infections: |
|
|
| Viral |
|
Decreased systemic immunity |
| Fungal |
|
Decreased systemic immunity |
| Salivary gland dysfunction |
| Altered oral flora (decreased
bacterial flora) |
| Bacterial |
Inadequate oral hygiene |
Decreased systemic immunity |
| Mucosal breakdown |
Salivary gland dysfunction |
| Acquired pathogens |
| Taste dysfunction |
Taste receptor toxicity |
|
| Xerostomia |
Salivary gland toxicity |
Anticholinergic drugs |
| Neuropathies |
Vinca alkaloid drug use; specific drug toxicity |
Anemia, dental hypersensitivity, temporomandibular dysfunction/myofascial pain |
| Dental and skeletal growth and development (pediatric patients) |
Specific drug toxicity |
Stage of dental and skeletal maturation |
| Gastrointestinal mucositis causing secondary changes in oral status including taste, hygiene, and dietary intake |
Mucosal cytotoxicity: radiation, chemotherapy |
Nausea and vomiting |
| Hemorrhage |
Oral mucositis
|
Thrombocytopenia |
| Physical trauma |
Decreased clotting factors (e.g., DIC) |
| Infections (e.g., HSV) |
