The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above.

Cellular Classification ¹

Added text ² to state that in a retrospective subset analysis, there was evidence that submicroscopic bone marrow and peripheral blood involvement were found in approximately 50% of patients and correlated with clinical stage; marrow involvement detected by PCR was associated with a 50% cumulative incidence of relapse (cited Damm-Welk et al. as reference 23).

Added Grewal et al. as reference 25 ².

Added text ³ to state that one report of children with primary CNS lymphoma showed that most patients had diffuse large B-cell lymphoma or ALCL and that therapy with high-dose intravenous methotrexate and cytosine arabinoside was most successful; intravenous chemotherapy may be needed only when malignant cells are present in the cerebral spinal fluid.

Stage Information ⁴

Added text ⁵ about the prevalence, clinical pattern, and outcome of CNS involvement in NHL patients (cited Salzburg et al. as reference 2).

Disseminated Childhood Anaplastic Large Cell Lymphoma ⁶

Added Grewal et al. as reference 6 ⁷.

Added text ⁷ to state that one study suggested that the amount of tumor involvement as measured by PCR in the marrow is predictive for relapse (cited Damm-Welk as reference 7).