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Table of Contents General Information About Late Effects
Central Nervous System
Senses
Digestive System
Spleen
Heart
Lung
Kidney
Thyroid
Neuroendocrine System
Musculoskeletal System
Reproductive System
Second Cancers
Mortality
Long-Term Follow-Up
To Learn More About Late Effects of Treatment for Childhood Cancer
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Changes to This Summary (07/01/2008)
About PDQ
General Information About Late Effects
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Late effects are treatment-related health problems that appear months or years after treatment has ended.
The treatment of cancer may damage healthy cells at the same time it destroys cancer cells. Some cancer treatments, such as chemotherapy, radiation therapy, and bone marrow or stem cell transplant, stop the growth of rapidly dividing cells, such as cancer cells. Since bones, tissues, and organs that are growing with the child have cells that are also dividing rapidly, cancer treatment can prevent them from developing normally. Other cancer treatments include surgery to remove all or part of certain organs that have cancer in them. The damage from these cancer treatments can be mild or serious, and the effects may be seen during treatment or months to years later.
Side effects that continue or appear after cancer treatment has ended are called late effects. It is important for the parents and the patient to know that children treated for cancer (childhood cancer survivors) may develop late effects from their treatment.
Late effects of cancer treatment may affect the following in childhood cancer survivors:
- Organs, bones, or body tissues.
- Mood, feelings, and actions.
- Thinking, learning, and memory.
The risk of developing late effects is related to the type of cancer or type of treatment.
The risk that a cancer treatment will cause late effects depends on many things, including the following:
- The type of cancer and where it is in the body.
- The child’s age (when treated).
- The type and amount of treatment.
- The area treated.
- Genetic factors or health problems the child had before the cancer.
Regular follow-up by health professionals who are expert in finding and treating late effects is important for the long-term health of childhood cancer survivors. Records about the cancer diagnosis and treatment, including all test results, should be kept by childhood cancer survivors (or their caregivers). This information may be used to help find and treat late effects.
Doctors are studying the late effects that cancer treatments cause in childhood cancer survivors. They are trying to find out if changing treatment can help prevent or lessen late effects in childhood cancer survivors.
Central Nervous System
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Cancer treatments to the central nervous system (CNS) may affect the child's brain.
Childhood cancer survivors who received radiation therapy to the head, brain surgery, or intrathecal chemotherapy are at risk of having problems in the following areas:
- Thinking.
- Learning.
- Problem solving.
- Speech.
- Reading.
- Writing.
- Memory.
- Coordinating movement between the eyes, hands, and other muscles.
Survivors may have learning disabilities or a lower IQ.
Certain factors increase the risk that CNS late effects will occur.
The following factors may increase the risk of CNS late effects:
- Being young at the time of treatment (the younger the child, the greater the risk).
- Having a tumor in the CNS.
- Receiving certain combinations of treatment, such as high-dose chemotherapy and radiation therapy to the brain.
CNS late effects may be caused by treatment for certain childhood cancers.
Treatment for these and other childhood cancers may cause CNS late effects:
Survivors of childhood cancer may have anxiety and depression related to their cancer.
Survivors of childhood cancer may have anxiety and depression related to physical changes, appearance, or the fear of cancer coming back. These problems may prevent survivors from returning to their normal routines and activities. They may also cause problems with personal relationships, education, employment, and health.
Some cancer survivors have post-traumatic stress disorder.
Being diagnosed with a life-threatening disease and receiving treatment for it is often traumatic. This trauma may cause a group of symptoms called post-traumatic stress disorder (PTSD). PTSD is defined as having certain symptoms following a stressful event that involved death or the threat of death, serious injury, or a threat to oneself or others. People who have survived very stressful situations, such as military combat or natural disasters, may also have PTSD.
PTSD can affect cancer survivors in the following ways:
- Reliving the time they were diagnosed and treated for cancer, in nightmares or flashbacks, and thinking about it all the time.
- Avoiding places, events, and people that remind them of the cancer experience.
- Being constantly overexcited, fearful, irritable, or unable to sleep, or having trouble concentrating.
Family problems, little or no social support from family or friends, and stress not related to the cancer may increase the chances of having PTSD. Because avoiding places and persons connected to the cancer is part of PTSD, survivors with PTSD may not try to get the medical treatment they need.
Senses
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Ears
Childhood cancer survivors may have late effects that affect hearing.
Certain factors increase the risk that hearing loss will occur.
The risk of hearing loss may be increased in childhood cancer survivors who received either of the following:
Risk may also be increased in childhood cancer survivors who were young at the time of treatment (the younger the child, the greater the risk).
Hearing late effects may be caused by treatment for certain childhood cancers.
Treatment for these and other childhood cancers may cause hearing late effects:
Eyes
Childhood cancer survivors may have late effects that affect the eyes.
Eye late effects may include the following:
- Bone growth problems around the eye socket that affect the shape of the child’s face as it grows.
- Dry eye.
- Cataracts.
- Damage to the optic nerve and retina.
- Poor vision.
- Drooping eyelids.
- Eyelid tumors.
Certain factors increase the risk that damage to the eye or eye socket will occur.
The following may increase the risk of damage to the eye or eye socket:
- Being younger than 1 year at the time of treatment.
- Tumor of the retina.
The risk may also be increased in childhood cancer survivors who had either of the following:
Eye late effects may be caused by radiation treatments for certain childhood cancers.
Radiation therapy for these and other childhood cancers may cause eye late effects:
Digestive System
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Teeth and jaw
Childhood cancer survivors may have late effects that affect the teeth and jaw.
Teeth and jaw late effects may include the following:
- Teeth are small or do not have a normal shape.
- The roots of the teeth are short.
- Missing teeth.
- New teeth come in at a later than normal age.
- The head and face do not reach full growth.
- Tooth enamel is not normal.
- Salivary glands do not make enough saliva.
- Tooth decay (including cavities) and gum disease.
Certain factors increase the risk that teeth and jaw late effects will occur.
The risk of teeth and jaw late effects may be increased in childhood cancer survivors who received any of the following:
Risk may also be increased in survivors who were younger than 3 years at the time of treatment.
It is important that childhood cancer survivors have regular dental checkups to help prevent or detect infection or decay.
Teeth and jaw late effects may be caused by treatment for certain childhood cancers.
Treatment for these and other childhood cancers may cause teeth and jaw late effects:
Liver
Childhood cancer survivors may have late effects that affect the liver.
Liver late effects may include the following:
Hepatic fibrosis, hepatitis C infection, and veno-occlusive disease can cause long-term problems.
Certain factors increase the risk that liver late effects will occur.
The risk of liver late effects may be increased in childhood cancer survivors who received any of the following:
Risk may also be increased in survivors who had liver disease before treatment or developed veno-occlusive disease during treatment.
Liver late effects may be caused by treatment for certain childhood cancers.
Treatment for these and other childhood cancers may cause liver late effects:
Digestive tract
Childhood cancer survivors may have late effects that affect the digestive tract.
Digestive tract late effects may include the following:
These effects may be caused by damage to the blood vessels, which may lead to long-term problems.
Radiation therapy to the abdomen may damage blood vessels and increase the risk of digestive tract late effects.
Digestive tract late effects may be caused by treatment for certain childhood cancers.
Treatment for these and other childhood cancers may cause digestive tract late effects:
Spleen
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Childhood cancer survivors may have late effects that affect the spleen.
Spleen late effects may increase the risk of life-threatening bacterial infections.
Certain factors increase the risk that spleen late effects will occur.
The risk of spleen late effects may be increased in childhood cancer survivors who received either of the following:
It is very important that childhood cancer survivors who received either of these treatments keep immunizations up-to-date and receive antibiotics before having any dental work.
Spleen late effects may be caused by treatment for childhood Hodgkin lymphoma and other childhood cancers.
Heart
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Childhood cancer survivors may have late effects that affect the heart.
Heart late effects may include the following:
- Abnormal heartbeat.
- Disease of the heart muscle.
- Congestive heart failure.
- Increased risk of stroke, blood clots, and chest pains.
- Tiring quickly during exercise.
- Coronary artery disease (hardening of the heart arteries).
Certain factors may increase the risk that heart late effects will occur.
The following may increase the risk of heart late effects:
This risk may also increase as the amounts of anthracycline drugs and radiation used increase and as the time since treatment gets longer.
Heart late effects may be caused by treatment for certain childhood cancers.
Treatment for these and other childhood cancers may cause heart late effects:
Lung
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Childhood cancer survivors may have late effects that affect the lungs.
Lung late effects may include the following:
Certain factors increase the risk that lung problems will occur.
The risk of lung late effects may be increased in childhood cancer survivors who had either of the following:
Risk may also be increased in survivors who received any of the following:
Lung late effects may be caused by treatment for certain childhood cancers.
Treatment for these and other childhood cancers may cause lung late effects:
Kidney
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Childhood cancer survivors may have late effects that affect the kidneys.
Kidney late effects may include the following:
Certain factors increase the risk that kidney problems will occur.
The following may increase the risk of kidney late effects:
- Having cancer in both kidneys.
- Being young at the time of treatment (the younger the child, the greater the risk).
- Having a genetic syndrome that increases the risk of kidney problems, such as Denys-Drash syndrome.
Risk may also be increased in childhood cancer survivors who received any of the following:
Kidney late effects may be caused by treatment for Wilms’ tumor and other childhood cancers.
Thyroid
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Childhood cancer survivors may have late effects that affect the thyroid.
Thyroid late effects may include the following:
Certain factors increase the risk that thyroid problems will occur.
The risk of thyroid late effects may be increased in childhood cancer survivors who received either of the following:
The risk may also be greater in females and may increase as the amount of time since diagnosis gets longer.
Thyroid late effects may be caused by treatment for certain childhood cancers.
Treatment for these and other childhood cancers may cause thyroid late effects:
Neuroendocrine System
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Childhood cancer survivors may have late effects that affect the neuroendocrine system.
Neuroendocrine late effects may include the following:
Childhood cancer survivors who received a stem cell transplant with total-body irradiation (TBI) have an increased risk of growth disorders.
Their risk is affected as follows:
- Low levels of growth hormone are more likely if the survivor:
- Adult height that is shorter than normal is more likely if the survivor:
- is male; or
- received the transplant at a young age; or
- received TBI in a single dose instead of divided doses.
Neuroendocrine late effects may be caused by treatment for certain childhood cancers.
Treatment for these and other childhood cancers may cause neuroendocrine late effects:
Musculoskeletal System
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Bone
Childhood cancer survivors may have late effects that affect the bones.
Bone late effects may include the following:
- Bone pain.
- Joint stiffness.
- Weak or thin bones that can break easily.
- Decreased amounts of calcium in bones.
- Decreased bone and tissue growth in treated areas.
Certain factors increase the risk that bone late effects will occur.
The following may increase the risk of bone late effects:
- Being female.
- Being older at the time of treatment.
- Having low levels of estrogen or growth hormone.
Risk may also be increased in childhood cancer survivors who received either of the following:
Bone late effects may be caused by treatment for certain childhood cancers.
Treatment for these and other childhood cancers may cause bone late effects:
Body weight
Childhood cancer survivors may have late effects that affect body weight and cause obesity.
The following may increase the risk of obesity:
- Being female and having received treatment at age 4 years or younger, with high- dose radiation therapy to the head.
- Being young at the time of treatment (the younger the child, the greater the risk).
- Being slender at the time of diagnosis.
- Having an increase in body fat at an earlier than normal age.
Obesity may be caused by treatment for certain childhood cancers.
Treatment for these and other childhood cancers may cause obesity:
Reproductive System
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Testicles
Childhood cancer survivors may have late effects that affect the testicles.
Testicular late effects may cause infertility or a low sperm count. Low sperm counts may be temporary or permanent depending on the radiation dose and schedule, the area of the body treated, and the age when treated.
Certain factors increase the risk that testicular late effects will occur.
The risk of testicular late effects may be increased in childhood cancer survivors who received either of the following:
Testicular late effects may be caused by treatment for certain childhood cancers.
Treatment for these and other childhood cancers may cause testicular late effects:
Ovaries
Childhood cancer survivors may have late effects that affect the ovaries.
Ovarian late effects may include the following:
Certain factors increase the risk that ovarian late effects will occur.
The risk of ovarian late effects may be increased in childhood | 
