The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above.

Prognostic Factors

Added Syndromes Associated with Osteosarcoma as a new subsection.

Treatment Option Overview

Added text to state that the Pediatric Oncology Group conducted a study in which patients were randomized either to immediate amputation or amputation after neoadjuvant therapy, but the study was terminated without approaching the stated accrual goals. In the small number of patients treated, there was no difference in outcome for those who received preoperative versus postoperative chemotherapy (added Goorin et al. as reference 3).

Localized Osteosarcoma/Malignant Fibrous Histiocytoma of Bone

Added Smeland et al. as reference 26.

Recurrent Osteosarcoma

Added Second Recurrence of Osteosarcoma as a new subsection.

Added text to state that the Cooperative Osteosarcoma Study group reported on 249 patients with a second recurrence of osteosarcoma treated with repeated surgical resection of recurrent disease. Of these patients, 197 died, 37 are alive in complete remission, and 15 remain alive who did not achieve surgical remission (added Bielack et al. as reference 36).

Added text about three protocols as examples of appropriate clinical trials for patients with metastatic disease.

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