Localized Osteosarcoma and Malignant Fibrous Histiocytoma of Bone
Metastatic Osteosarcoma and Malignant Fibrous Histiocytoma of Bone
Recurrent Osteosarcoma and Malignant Fibrous Histiocytoma of Bone

A link to a list of current clinical trials is included for each treatment section. For some types or stages of cancer, there may not be any trials listed. Check with your doctor for clinical trials that are not listed here but may be right for you.

Treatment may include the following:

• Surgery followed by adjuvant chemotherapy or radiation therapy. Most patients also receive chemotherapy before the surgery.
• Radiation therapy when the tumor cannot be completely removed by surgery.
• A clinical trial of chemotherapy given before and after surgery, with or without biologic therapy.

Check for U.S. clinical trials from NCI's PDQ Cancer Clinical Trials Registry that are now accepting patients with localized osteosarcoma and localized childhood malignant fibrous histiocytoma of bone. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. General information about clinical trials is available from the NCI Web site.

Lung Metastasis

When osteosarcoma or malignant fibrous histiocytoma (MFH) spread, it usually spreads to the lung. Treatment of osteosarcoma and MFH with lung metastasis is usually chemotherapy followed by surgery to remove the cancer that has spread to the lung.

Bone Metastasis or Bone with Lung Metastasis

Osteosarcoma and malignant fibrous histiocytoma may spread to bone and/or the lung. Treatment may include the following:

• Chemotherapy followed by surgery to remove the cancer followed by combination chemotherapy.
• Surgery to remove the primary tumor followed by chemotherapy and surgery to remove cancer that has spread to other parts of the body.
• A clinical trial of chemotherapy given before and after surgery, with or without biologic therapy.

Check for U.S. clinical trials from NCI's PDQ Cancer Clinical Trials Registry that are now accepting patients with metastatic osteosarcoma and metastatic childhood malignant fibrous histiocytoma of bone. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. General information about clinical trials is available from the NCI Web site.

Treatment of recurrent osteosarcoma and malignant fibrous histiocytoma of bone may include the following:

• Surgery to remove the tumor with or without chemotherapy.
• Samarium followed by stem cell transplant using the patient's own stem cells, as palliative treatment to relieve pain and improve the quality of life.
• A clinical trial of new types of treatment for patients whose cancer cannot be removed by surgery.

Check for U.S. clinical trials from NCI's PDQ Cancer Clinical Trials Registry that are now accepting patients with recurrent osteosarcoma and recurrent childhood malignant fibrous histiocytoma of bone. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. General information about clinical trials is available from the NCI Web site.

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